Increased nuisance of multidrug resistant bacteria is a serious health problem these days. Persistent use of broad spectrum antibiotics is ceasing the efficacy of antibiotics. Phage induced bacterial lysis represents the bactericidal effect–phage therapy. Safe and effective use of bacterial viruses is showing good potential against multidrug resistant bacteria. Phage therapy has some disadvantages but it seems to be a good option for this problem. Phage resistance can also be overcome using phage cocktails-polyphage therapy. Phage structure, its ability to destruct the bacterial cell, hollins and endolysins activity, pros and cons of the therapy are the important aspects to be considered during phage treatment. Though phage therapy is better alternate for multidrug resistance, rigorous research work and extensive regulatory control is needed.
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